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klp-17 Kinesin motor domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174750, updated on 4-Jan-2025

Summary

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Official Symbol
klp-17
Official Full Name
Kinesin motor domain-containing protein
Primary source
WormBase:WBGene00002227
Locus tag
CELE_W02B12.7
See related
AllianceGenome:WB:WBGene00002227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable microtubule binding activity. Involved in chromosome segregation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in microtubule cytoskeleton. Is expressed in germ line and sperm. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See klp-17 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (11465940..11467641, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative splicing factor, arginine/serine-rich 1 Neighboring gene pseudo Neighboring gene Alanine--tRNA ligase, mitochondrial Neighboring gene Rho GTPase-activating protein 68F;Rho-GAP domain-containing protein Neighboring gene CDGSH iron-sulfur domain-containing protein 2 homologue;Iron-binding zinc finger CDGSH type domain-containing protein Neighboring gene Mitoferrin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Essential kinesins: characterization of Caenorhabditis elegans KLP-15. Robin G, et al. Biochemistry, 2005 May 3. PMID 15850386
  2. Structure and biological evaluation of Caenorhabditis elegans CISD-1/mitoNEET, a KLP-17 tail domain homologue, supports attenuation of paraquat-induced oxidative stress through a p38 MAPK-mediated antioxidant defense response. Boos JR, et al. Adv Redox Res, 2022 Dec. PMID 36533211, Free PMC Article
  3. A novel C-terminal kinesin subfamily may be involved in chromosomal movement in caenorhabditis elegans. Ali MY, et al. FEBS Lett, 2000 Mar 17. PMID 10722848
  4. cDNA cloning and expression of a C-terminus motor kinesin-like protein KLP-17, involved in chromosomal movement in Caenorhabditis elegans. Ali MY, et al. Biochem Biophys Res Commun, 2000 Jan 19. PMID 10631116
  5. Metazoan motor models: kinesin superfamily in C. elegans. Siddiqui SS. Traffic, 2002 Jan. PMID 11872139

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Kinesin motor domain-containing protein
NP_496446.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11465940..11467641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064045.6 → NP_496446.3  Kinesin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496446.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23124
    Conserved Domains (3) summary
    PRK03992
    Location:70 → 116
    PRK03992; proteasome-activating nucleotidase; Provisional
    smart00129
    Location:145 → 464
    KISc; Kinesin motor, catalytic domain. ATPase
    TIGR04523
    Location:11 → 146
    Mplasa_alph_rch; helix-rich Mycoplasma protein
Nucleotide Protein
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