shn-1 Protein shank [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: shn-1
Official Full Name: Protein shank
Primary source: WormBase:WBGene00006444
Locus tag: CELE_C33B4.3
See related: AllianceGenome:WB:WBGene00006444
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Involved in defecation and rhythmic behavior. Predicted to be located in cytoplasmic vesicle; pseudopodium; and synapse. Predicted to be active in dendritic spine and postsynaptic density. Predicted to colocalize with postsynaptic membrane. Is expressed in several structures, including epithelial cell; neurons; pharyngeal-intestinal valve; somatic nervous system; and sperm. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome; autistic disorder; and schizophrenia 15. Orthologous to several human genes including SHANK1 (SH3 and multiple ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See shn-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 12

Sequence:: Chromosome: II; NC_003280.10 (11384466..11390965, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Shank promotes action potential repolarization by recruiting BK channels to calcium microdomains.
Title: Shank promotes action potential repolarization by recruiting BK channels to calcium microdomains.
Regulation of Innate Immune Response to Fungal Infection in Caenorhabditis elegans by SHN-1/SHANK.
Title: Regulation of Innate Immune Response to Fungal Infection in Caenorhabditis elegans by SHN-1/SHANK.
Here the authors show that the Caenorhabditis elegans SHN-1/Shank binds L-type calcium channels and that increased and decreased shn-1 gene dosage alter L-channel current and activity-induced expression of a CRH-1/CREB transcriptional target (gem-4 Copine).
Title: Shank is a dose-dependent regulator of Ca(v)1 calcium current and CREB target expression.
Shank ANK repeat-domain along with PDZ may play a crucial role in regulating calcium signaling with inositol triphosphate receptor
Title: ANK repeat-domain of SHN-1 Is indispensable for in vivo SHN-1 function in C. elegans.
SHN-1 protein is localized in various tissues including neurons, pharynx and intestine. Suppression of SHN-1 did not cause lethality or developmental abnormality, but resulted in altered defecation rhythm in a strain with mutated IP(3)receptor.
Title: SHN-1, a Shank homologue in C. elegans, affects defecation rhythm via the inositol-1,4,5-trisphosphate receptor.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C33B4.3 (e-PCR)
- UniSTS:309220

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables synaptic receptor adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defecation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in rhythmic behavior	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in pseudopodium	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein shank

NP_001022006.1

Confirmed by transcript evidence

NP_001022007.1

Confirmed by transcript evidence

NP_001379494.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11384466..11390965 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026836.6 → NP_001022007.1 Protein shank [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022007.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7WN72

Conserved Domains (5) summary

cd00204
Location:206 → 330

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd00992
Location:435 → 526

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12796
Location:220 → 310

Ank_2; Ankyrin repeats (3 copies)

pfam16511
Location:10 → 91

FERM_f0; N-terminal or F0 domain of Talin-head FERM

sd00045
Location:178 → 209

ANK; ANK repeat [structural motif]
NM_001393191.1 → NP_001379494.1 Protein shank [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

B7WN72, Q09493, Q7JMK1

Conserved Domains (5) summary

cd09506
Location:1074 → 1139

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03095
Location:116 → 317

PHA03095; ankyrin-like protein; Provisional

cd00992
Location:435 → 526

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:178 → 209

ANK; ANK repeat [structural motif]

cd17091
Location:8 → 91

FERM_F0_SHANK; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains proteins, SHANK1, SHANK2, and SHANK3
NM_001026835.7 → NP_001022006.1 Protein shank [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022006.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7WN72

Conserved Domains (7) summary

cd09506
Location:1044 → 1109

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

smart00454
Location:1045 → 1110

SAM; Sterile alpha motif

cd00204
Location:206 → 330

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd00992
Location:435 → 526

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12796
Location:220 → 310

Ank_2; Ankyrin repeats (3 copies)

pfam16511
Location:10 → 91

FERM_f0; N-terminal or F0 domain of Talin-head FERM

sd00045
Location:178 → 209

ANK; ANK repeat [structural motif]