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T06D8.9 Store-operated calcium entry-associated regulatory factor [ Caenorhabditis elegans ]

Gene ID: 174716, updated on 2-Nov-2024

Summary

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Official Symbol
T06D8.9
Official Full Name
Store-operated calcium entry-associated regulatory factor
Primary source
WormBase:WBGene00011529
Locus tag
CELE_T06D8.9
See related
AllianceGenome:WB:WBGene00011529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SARAF (store-operated calcium entry associated regulatory factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T06D8.9 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (11239718..11240986)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene FUN14 domain-containing protein fndc-1 Neighboring gene ncRNA Neighboring gene 26S proteasome non-ATPase regulatory subunit 13 Neighboring gene Peroxidase Neighboring gene ncRNA Neighboring gene Apple domain-containing protein Neighboring gene Nuclear receptor domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of store-operated calcium entry IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Store-operated calcium entry-associated regulatory factor
NP_496406.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11239718..11240986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064005.7 → NP_496406.2  Store-operated calcium entry-associated regulatory factor [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496406.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22254
    Conserved Domains (1) summary
    pfam06682
    Location:13 → 316
    SARAF; SOCE-associated regulatory factor of calcium homoeostasis
Nucleotide Protein
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