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fndc-1 FUN14 domain-containing protein fndc-1 [ Caenorhabditis elegans ]

Gene ID: 174714, updated on 4-Jan-2025

Summary

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Official Symbol
fndc-1
Official Full Name
FUN14 domain-containing protein fndc-1
Primary source
WormBase:WBGene00011528
Locus tag
CELE_T06D8.7
See related
AllianceGenome:WB:WBGene00011528
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in mitophagy. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human FUNDC1 (FUN14 domain containing 1) and FUNDC2 (FUN14 domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See fndc-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (11236624..11237325, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene UVR domain-containing protein Neighboring gene EOG090X04TT Neighboring gene putative holocytochrome-c-type synthase Neighboring gene ncRNA Neighboring gene 26S proteasome non-ATPase regulatory subunit 13 Neighboring gene Store-operated calcium entry-associated regulatory factor Neighboring gene Peroxidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fndc-1 contributes to paternal mitochondria elimination in C. elegans. Lim Y, et al. Dev Biol, 2019 Oct 1. PMID 31233739, Free PMC Article
  2. FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation. Lim Y, et al. Autophagy, 2021 Nov. PMID 33416042, Free PMC Article
  3. Ubiquitination is required for the initial removal of paternal organelles in C. elegans. Molina P, et al. Dev Biol, 2019 Sep 15. PMID 31153831, Free PMC Article
  4. A novel biochemical method to identify target genes of individual microRNAs: identification of a new Caenorhabditis elegans let-7 target. Andachi Y. RNA, 2008 Nov. PMID 18824511, Free PMC Article
  5. Molecular definitions of autophagy and related processes. Galluzzi L, et al. EMBO J, 2017 Jul 3. PMID 28596378, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation.
    Title: FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FUN14 domain-containing protein fndc-1
NP_496404.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11236624..11237325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064003.7 → NP_496404.1  FUN14 domain-containing protein fndc-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496404.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22252
    Conserved Domains (1) summary
    pfam04930
    Location:41 → 135
    FUN14; FUN14 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22252.1

Gene LinkOut

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