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cchl-1 putative holocytochrome-c-type synthase [ Caenorhabditis elegans ]

Gene ID: 174713, updated on 2-Nov-2024

Summary

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Official Symbol
cchl-1
Official Full Name
putative holocytochrome-c-type synthase
Primary source
WormBase:WBGene00011527
Locus tag
CELE_T06D8.6
See related
AllianceGenome:WB:WBGene00011527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable holocytochrome-c synthase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cchl-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (11235052..11236387, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein Neighboring gene ncRNA Neighboring gene UVR domain-containing protein Neighboring gene EOG090X04TT Neighboring gene FUN14 domain-containing protein fndc-1 Neighboring gene ncRNA Neighboring gene 26S proteasome non-ATPase regulatory subunit 13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Yoon JC, et al. Proc Natl Acad Sci U S A, 2014 Mar 11. PMID 24556985, Free PMC Article
  2. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. Hansen M, et al. PLoS Genet, 2005 Jul. PMID 16103914, Free PMC Article
  3. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
  4. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373
  5. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables holocytochrome-c synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables holocytochrome-c synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative holocytochrome-c-type synthase
NP_496403.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11235052..11236387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064002.8 → NP_496403.1  putative holocytochrome-c-type synthase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496403.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53703
    Conserved Domains (1) summary
    pfam01265
    Location:34 → 251
    Cyto_heme_lyase; Cytochrome c/c1 heme lyase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53703.1

Gene LinkOut

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