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cap-2 F-actin-capping protein subunit beta [ Caenorhabditis elegans ]

Gene ID: 174673, updated on 4-Jan-2025

Summary

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Official Symbol
cap-2
Official Full Name
F-actin-capping protein subunit beta
Primary source
WormBase:WBGene00000293
Locus tag
CELE_M106.5
See related
AllianceGenome:WB:WBGene00000293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables actin filament binding activity. Involved in actin cytoskeleton organization and embryonic axis specification. Located in cytoplasm. Part of dynactin complex. Is expressed in hypodermis; pharynx; and tail. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cap-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (10869196..10870827)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Prostaglandin reductase 2 Neighboring gene putative GMP synthase [glutamine-hydrolyzing] Neighboring gene ncRNA Neighboring gene Peptidyl-prolyl cis-trans isomerase 4 Neighboring gene putative coatomer subunit zeta Neighboring gene Origin recognition complex subunit 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The alpha and beta subunits of nematode actin capping protein function in yeast. Waddle JA, et al. Mol Biol Cell, 1993 Sep. PMID 8257793, Free PMC Article
  2. Establishment of initial asymmetry in early Caenorhabditis elegans embryos. Priess JR. Curr Opin Genet Dev, 1994 Aug. PMID 7950325
  3. TAC-1, a regulator of microtubule length in the C. elegans embryo. Le Bot N, et al. Curr Biol, 2003 Sep 2. PMID 12956951
  4. Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Terasawa M, et al. Genes Cells, 2010 Nov. PMID 20964796, Free PMC Article
  5. Actin-capping protein regulates actomyosin contractility to maintain germline architecture in C. elegans. Ray S, et al. Development, 2023 Mar 15. PMID 36897576, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryonic axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of F-actin capping protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of F-actin capping protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynactin complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
F-actin-capping protein subunit beta
NP_496336.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10869196..10870827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063935.10 → NP_496336.1  F-actin-capping protein subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496336.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34686
    Conserved Domains (1) summary
    pfam01115
    Location:11 → 238
    F_actin_cap_B; F-actin capping protein, beta subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34686.1

Gene LinkOut

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