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gpd-1 Glyceraldehyde-3-phosphate dehydrogenase 1 [ Caenorhabditis elegans ]

Gene ID: 174603, updated on 4-Jan-2025

Summary

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Official Symbol
gpd-1
Official Full Name
Glyceraldehyde-3-phosphate dehydrogenase 1
Primary source
WormBase:WBGene00001683
Locus tag
CELE_T09F3.3
See related
AllianceGenome:WB:WBGene00001683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Predicted to be involved in glycolytic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in germ line. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDH (glyceraldehyde-3-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See gpd-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (10394129..10395349)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene 39S ribosomal protein L22, mitochondrial Neighboring gene RNase H type-1 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dithianon exposure induces dopaminergic neurotoxicity in Caenorhabditis elegans. Lee Y, et al. Ecotoxicol Environ Saf, 2023 Apr 15. PMID 36924561
  2. Two isoenzymes of glyceraldehyde-3-phosphate dehydrogenase in Caenorhabditis elegans. Isolation, properties, and immunochemical characterization. Yarbrough PO, et al. J Biol Chem, 1984 Dec 10. PMID 6389551
  3. Cloning of a trans-spliced glyceraldehyde-3-phosphate-dehydrogenase gene from the potato cyst nematode Globodera rostochiensis and expression of its putative promoter region in Caenorhabditis elegans. Qin L, et al. Mol Biochem Parasitol, 1998 Oct 30. PMID 9851607
  4. Conservation of gene organization and trans-splicing in the glyceraldehyde-3-phosphate dehydrogenase-encoding genes of Caenorhabditis briggsae. Lee YH, et al. Gene, 1992 Nov 16. PMID 1446820
  5. Genomic organization of the glyceraldehyde-3-phosphate dehydrogenase gene family of Caenorhabditis elegans. Huang XY, et al. J Mol Biol, 1989 Apr 5. PMID 2716055

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Glyceraldehyde-3-phosphate dehydrogenase 1
NP_496237.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10394129..10395349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063836.7 → NP_496237.1  Glyceraldehyde-3-phosphate dehydrogenase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496237.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P04970
    Conserved Domains (3) summary
    PTZ00023
    Location:6 → 337
    PTZ00023; glyceraldehyde-3-phosphate dehydrogenase; Provisional
    pfam00044
    Location:5 → 158
    Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
    pfam02800
    Location:163 → 320
    Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04970.1

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