aqp-2 Aquaporin-9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aqp-2
Official Full Name: Aquaporin-9
Primary source: WormBase:WBGene00000170
Locus tag: CELE_C01G6.1
See related: AllianceGenome:WB:WBGene00000170
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables water channel activity. Involved in water transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in excretory cell; hypodermis; and muscle cell. Orthologous to several human genes including AQP10 (aquaporin 10); AQP3 (aquaporin 3 (Gill blood group)); and AQP7 (aquaporin 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See aqp-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (9259048..9261981, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans.
Title: Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C01G6.1a (e-PCR)
- UniSTS:319889

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables channel activity	IEA Inferred from Electronic Annotation more info
enables glycerol channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in glycerol transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyol transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in urea transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in water transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Aquaporin-9

NP_001366692.1

Partially confirmed by transcript evidence

NP_001379056.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9259048..9261981 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381560.2 → NP_001366692.1 Aquaporin-9 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q7JMQ6

Conserved Domains (1) summary

cd00333
Location:18 → 254

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_001393149.1 → NP_001379056.1 Aquaporin-9 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q17571, Q9U3S2

Conserved Domains (1) summary

cd00333
Location:18 → 254

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...