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sec-5 Exocyst complex component 2 [ Caenorhabditis elegans ]

Gene ID: 174459, updated on 4-Jan-2025

Summary

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Official Symbol
sec-5
Official Full Name
Exocyst complex component 2
Primary source
WormBase:WBGene00004752
Locus tag
CELE_T23G7.4
See related
AllianceGenome:WB:WBGene00004752
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be part of exocyst. Is expressed in several structures, including anal depressor muscle; excretory canal; hermaphrodite somatic gonadal cell; intestine; and tail neurons. Orthologous to human EXOC2 (exocyst complex component 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sec-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
12
Sequence:
Chromosome: II; NC_003280.10 (9173166..9177152, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene G-patch domain-containing protein Neighboring gene Calcineurin-like phosphoesterase domain-containing protein Neighboring gene Transcription factor dpl-1 Neighboring gene RNA/RNP complex-1-interacting phosphatase homolog Neighboring gene RNA-binding protein sym-2;RRM domain-containing protein Neighboring gene Potassium channel domain-containing protein Neighboring gene Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins. Armenti ST, et al. Development, 2014 Dec. PMID 25377555, Free PMC Article
  2. RAL-1 controls multivesicular body biogenesis and exosome secretion. Hyenne V, et al. J Cell Biol, 2015 Oct 12. PMID 26459596, Free PMC Article
  3. RAL-1 signaling regulates lipid composition in C. elegans. Wu Y, et al. MicroPubl Biol, 2024. PMID 38454952, Free PMC Article
  4. RAB-10 Regulates Dendritic Branching by Balancing Dendritic Transport. Taylor CA, et al. PLoS Genet, 2015 Dec. PMID 26633194, Free PMC Article
  5. Polarized exocyst-mediated vesicle fusion directs intracellular lumenogenesis within the C. elegans excretory cell. Armenti ST, et al. Dev Biol, 2014 Oct 1. PMID 25102190, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst IEA
Inferred from Electronic Annotation
more info
  
part_of exocyst ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Exocyst complex component 2
NP_495958.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9173166..9177152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063557.7 → NP_495958.1  Exocyst complex component 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495958.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22706
    Conserved Domains (2) summary
    pfam01833
    Location:13 → 95
    TIG; IPT/TIG domain
    pfam15469
    Location:201 → 377
    Sec5; Exocyst complex component Sec5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22706.1

Gene LinkOut

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