U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cct-2 T-complex protein 1 subunit beta [ Caenorhabditis elegans ]

Gene ID: 174421, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
cct-2
Official Full Name
T-complex protein 1 subunit beta
Primary source
WormBase:WBGene00000378
Locus tag
CELE_T21B10.7
See related
AllianceGenome:WB:WBGene00000378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytosol. Predicted to be part of chaperonin-containing T-complex. Is expressed in several structures, including alimentary muscle; body wall musculature; hypodermis; tail; and touch receptor neurons. Orthologous to human CCT2 (chaperonin containing TCP1 subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cct-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (8927741..8929815)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Expressed conserved protein Neighboring gene Glycine-rich protein Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein mL50 Neighboring gene Enolase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Shigella flexneri infection in Caenorhabditis elegans: cytopathological examination and identification of host responses. George DT, et al. PLoS One, 2014. PMID 25187942, Free PMC Article
  2. Characterization of four new tcp-1-related cct genes from the nematode Caenorhabditis elegans. Leroux MR, et al. DNA Cell Biol, 1995 Nov. PMID 7576182
  3. Postembryonic RNAi in Heterorhabditis bacteriophora: a nematode insect parasite and host for insect pathogenic symbionts. Ciche TA, et al. BMC Dev Biol, 2007 Sep 5. PMID 17803822, Free PMC Article
  4. Caenorhabditis elegans chaperonin CCT/TRiC is required for actin and tubulin biogenesis and microvillus formation in intestinal epithelial cells. Saegusa K, et al. Mol Biol Cell, 2014 Oct 15. PMID 25143409, Free PMC Article
  5. An RNAi screen for genes that affect nuclear morphology in Caenorhabditis elegans reveals the involvement of unexpected processes. Maheshwari R, et al. G3 (Bethesda), 2021 Oct 19. PMID 34849797, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chaperonin-containing T-complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
T-complex protein 1 subunit beta
NP_741031.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8927741..8929815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171985.8 → NP_741031.1  T-complex protein 1 subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741031.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47207, Q22628
    Conserved Domains (2) summary
    cd03336
    Location:6 → 520
    TCP1_beta; TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02341
    Location:5 → 522
    chap_CCT_beta; T-complex protein 1, beta subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47207.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.