pyr-1 Glutamine-dependent carbamoyl-phosphate synthase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pyr-1
Official Full Name: Glutamine-dependent carbamoyl-phosphate synthase
Primary source: WormBase:WBGene00004259
Locus tag: CELE_D2085.1
See related: AllianceGenome:WB:WBGene00004259
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable aspartate carbamoyltransferase activity and dihydroorotase activity. Predicted to contribute to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. Involved in several processes, including nematode pharyngeal gland morphogenesis; nematode pharynx development; and pyrimidine nucleobase biosynthetic process. Predicted to be active in cytosol. Is expressed in intestine. Used to study carbamoyl phosphate synthetase I deficiency disease and orotic aciduria. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 50. Orthologous to human CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pyr-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (8651109..8658726)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pyr-1 functions upstream of proteoglycan synthesizing enzymes by providing precursors of UDP-sugars essential for heparan sulfate proteoglycan synthesis.
Title: C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2085.1 (e-PCR)
- UniSTS:309489

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables amino acid binding	IEA Inferred from Electronic Annotation more info
enables aspartate carbamoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartate carbamoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables carbamoyl-phosphate synthase (ammonia) activity	IEA Inferred from Electronic Annotation more info
contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
enables carboxyl- or carbamoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dihydroorotase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydroorotase activity	IEA Inferred from Electronic Annotation more info
enables glutaminase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyrimidine nucleobase biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Glutamine-dependent carbamoyl-phosphate synthase

NP_495838.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8651109..8658726

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063437.7 → NP_495838.2 Glutamine-dependent carbamoyl-phosphate synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495838.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18990

Conserved Domains (4) summary

COG0505
Location:1 → 364

CarA; Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism, Nucleotide transport and metabolism]

cd01316
Location:1472 → 1817

CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...

cl27385
Location:1877 → 2194

OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain

cl27719
Location:391 → 1452

Biotin_carb_N; Biotin carboxylase, N-terminal domain