zyg-9 Zygote defective protein 9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: zyg-9
Official Full Name: Zygote defective protein 9
Primary source: WormBase:WBGene00006994
Locus tag: CELE_F22B5.7
See related: AllianceGenome:WB:WBGene00006994
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable microtubule binding activity and microtubule plus end polymerase. Involved in embryo development; meiotic spindle organization; and spindle elongation. Located in cytoplasm; kinetochore; and microtubule cytoskeleton. Orthologous to human CKAP5 (cytoskeleton associated protein 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See zyg-9 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (8457818..8464512)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zyg9, the XMAP215/Dis1 homolog in C. elegans exhibits a polymerase activity which is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region.
Title: XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region.
These findings indicate that ZYG-9-TAC-1 and ZYG-8 act in a partially redundant manner to ensure correct microtubule assembly throughout the cell cycle of early C. elegans embryos.
Title: ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos.
Positioning of the germinal vesicle is dependent on zyg-9.
Title: MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elegans.
ZYG-9 and TAC-1 physically interact in vivo, and this interaction is important for the efficient localization of the ZYG-9/TAC-1 complex to centrosomes
Title: Caenorhabditis elegans TAC-1 and ZYG-9 form a complex that is essential for long astral and spindle microtubules.
mutual stabilization between TACC and Zyg-9 proteins is a key feature ensuring microtubule assembly in vivo
Title: TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F22B5.7 (e-PCR)
- UniSTS:321391

F22B5.8 (e-PCR)
- UniSTS:321392

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables microtubule plus end polymerase	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus end polymerase	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome duplication	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	IEA Inferred from Electronic Annotation more info
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intracellular membraneless organelle	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
colocalizes_with microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in supramolecular complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Zygote defective protein 9

NP_495784.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8457818..8464512

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063383.7 → NP_495784.1 Zygote defective protein 9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495784.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EEM5

Conserved Domains (1) summary

sd00044
Location:16 → 47

HEAT; HEAT repeat [structural motif]