U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

efl-3 Transcription factor efl-3 [ Caenorhabditis elegans ]

Gene ID: 174341, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
efl-3
Official Full Name
Transcription factor efl-3
Primary source
WormBase:WBGene00009899
Locus tag
CELE_F49E12.6
See related
AllianceGenome:WB:WBGene00009899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in developing hermaphrodite gonad; intestine; neurons; and ventral nerve cord. Orthologous to several human genes including E2F8 (E2F transcription factor 8). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See efl-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (8412671..8416857)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene UBC core domain-containing protein Neighboring gene Serpentine receptor class alpha-13 Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene pseudo Neighboring gene IBB domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hox and a newly identified E2F co-repress cell death in Caenorhabditis elegans. Winn J, et al. Genetics, 2011 Aug. PMID 21596899, Free PMC Article
  2. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Curran SP, et al. Nature, 2009 Jun 25. PMID 19506556, Free PMC Article
  3. Gene expression profiling of epidermal cell types in C. elegans using Targeted DamID. Katsanos D, et al. Development, 2021 Sep 1. PMID 34397094, Free PMC Article
  4. mRNA profiling reveals significant transcriptional differences between a multipotent progenitor and its differentiated sister. Mathies LD, et al. BMC Genomics, 2019 May 28. PMID 31138122, Free PMC Article
  5. Transcription factors regulating the fate and developmental potential of a multipotent progenitor in Caenorhabditis elegans. Soukup EM, et al. G3 (Bethesda), 2022 Nov 4. PMID 36063055, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Transcription factor efl-3
NP_495771.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8412671..8416857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063370.8 → NP_495771.2  Transcription factor efl-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495771.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20619
    Conserved Domains (2) summary
    pfam02319
    Location:97 → 164
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam03154
    Location:457 → 532
    Atrophin-1; Atrophin-1 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20619.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools