nst-1 Guanine nucleotide-binding protein-like 3 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nst-1
Official Full Name: Guanine nucleotide-binding protein-like 3 homolog
Primary source: WormBase:WBGene00003821
Locus tag: CELE_K01C8.9
See related: AllianceGenome:WB:WBGene00003821
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity. Involved in germ cell development; nematode larval development; and regulation of growth. Located in nucleolus and nucleoplasm. Is expressed widely. Used to study obesity. Orthologous to several human genes including GNL3L (G protein nucleolar 3 like). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nst-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (8281162..8283208, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nucleostemin plays roles in cell growth and proliferation by promoting ribosome biogenesis.
Title: C. elegans nucleostemin is required for larval growth and germline stem cell division.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K01C8.9 (e-PCR)
- UniSTS:311345

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Guanine nucleotide-binding protein-like 3 homolog

NP_495749.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8281162..8283208 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063348.7 → NP_495749.1 Guanine nucleotide-binding protein-like 3 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495749.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21086

Conserved Domains (4) summary

cd04178
Location:149 → 314

Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases

COG1161
Location:140 → 439

RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

pfam08701
Location:17 → 84

GN3L_Grn1; GNL3L/Grn1 putative GTPase

cl21455
Location:263 → 401

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases