mig-5 Segment polarity protein dishevelled homolog mig-5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mig-5
Official Full Name: Segment polarity protein dishevelled homolog mig-5
Primary source: WormBase:WBGene00003241
Locus tag: CELE_T05C12.6
See related: AllianceGenome:WB:WBGene00003241
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable frizzled binding activity. Involved in several processes, including cell fate specification; inductive cell migration; and non-canonical Wnt signaling pathway. Located in cell cortex. Is expressed in several structures, including distal tip cell; head; hypodermis; posterior lateral left ganglion; and somatic gonad precursor. Human ortholog(s) of this gene implicated in DiGeorge syndrome; autosomal dominant Robinow syndrome 2; autosomal dominant Robinow syndrome 3; and lung cancer. Orthologous to human DVL1 (dishevelled segment polarity protein 1); DVL2 (dishevelled segment polarity protein 2); and DVL3 (dishevelled segment polarity protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mig-5 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (8182323..8185023, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DSH-2 and MIG-5 regulate cell fate, beta-catenin nuclear levels and the polarity of beta-catenin regulation.
Title: Unique and redundant β-catenin regulatory roles of two Dishevelled paralogs during C. elegans asymmetric cell division.
These defects demonstrate that MIG-5 is essential in determining proper cell fate and cell migration throughout C. elegans development.
Title: mig-5/Dsh controls cell fate determination and cell migration in C. elegans.
a novel planar cell polarity (PCP)-like pathway, in which LIN-17 and MIG-5 are asymmetrically localized, is involved in the regulation of B cell polarity
Title: Asymmetric localizations of LIN-17/Fz and MIG-5/Dsh are involved in the asymmetric B cell division in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T05C12.7 (e-PCR)
- UniSTS:306082

T05C12.6 (e-PCR)
- UniSTS:307924

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IC Inferred by Curator more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Wnt signaling pathway, regulating spindle positioning	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Wnt signaling pathway, regulating spindle positioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification involved in pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermis morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inductive cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in left/right axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death involved in cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment or maintenance of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction involved in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Segment polarity protein dishevelled homolog mig-5

NP_001022316.1

Confirmed by transcript evidence

NP_001022317.1

Confirmed by transcript evidence

NP_001022318.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8182323..8185023 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027147.5 → NP_001022318.1 Segment polarity protein dishevelled homolog mig-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022318.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22227

Conserved Domains (3) summary

smart00021
Location:9 → 92

DAX; Domain present in Dishevelled and axin

cd00992
Location:237 → 294

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:378 → 460

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
NM_001027145.4 → NP_001022316.1 Segment polarity protein dishevelled homolog mig-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022316.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EC49, O76471, Q22227, Q95ZQ0

Conserved Domains (3) summary

smart00021
Location:9 → 92

DAX; Domain present in Dishevelled and axin

cd00992
Location:237 → 305

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:419 → 501

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
NM_001027146.3 → NP_001022317.1 Segment polarity protein dishevelled homolog mig-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022317.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22227

Conserved Domains (3) summary

smart00021
Location:9 → 92

DAX; Domain present in Dishevelled and axin

cd00992
Location:237 → 305

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:419 → 501

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...