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T05H10.1 Ubiquitin carboxyl-terminal hydrolase 47 [ Caenorhabditis elegans ]

Gene ID: 174290, updated on 4-Jan-2025

Summary

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Official Symbol
T05H10.1
Official Full Name
Ubiquitin carboxyl-terminal hydrolase 47
Primary source
WormBase:WBGene00011507
Locus tag
CELE_T05H10.1
See related
AllianceGenome:WB:WBGene00011507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type deubiquitinase activity. Involved in anterior/posterior axis specification, embryo. Located in cytoplasm. Is expressed in germ line and nervous system. Orthologous to human USP47 (ubiquitin specific peptidase 47). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See T05H10.1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (8042589..8047452)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Ubiquitin carboxyl-terminal hydrolase ubh-4 Neighboring gene putative dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase Neighboring gene Apurinic-apyrimidinic endonuclease Neighboring gene Male Tail tip Retraction Expression Neighboring gene FLYWCH-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deubiquitylation machinery is required for embryonic polarity in Caenorhabditis elegans. McCloskey RJ, et al. PLoS Genet, 2012. PMID 23209443, Free PMC Article
  2. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior axis specification, embryo IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ubiquitin carboxyl-terminal hydrolase 47
NP_495686.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8042589..8047452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063285.9 → NP_495686.2  Ubiquitin carboxyl-terminal hydrolase 47 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495686.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22240
    Conserved Domains (1) summary
    cd02659
    Location:86 → 477
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
Nucleotide Protein
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