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cec-3 Chromo domain-containing protein cec-3 [ Caenorhabditis elegans ]

Gene ID: 174265, updated on 2-Nov-2024

Summary

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Official Symbol
cec-3
Official Full Name
Chromo domain-containing protein cec-3
Primary source
WormBase:WBGene00011636
Locus tag
CELE_T09A5.8
See related
AllianceGenome:WB:WBGene00011636
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity and methylated histone binding activity. Involved in negative regulation of gene expression. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cec-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (7855810..7857600, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Mediator of RNA polymerase II transcription subunit 10 Neighboring gene MitochonDrial interMembrane space protein Homolog Neighboring gene Small integral membrane protein 26 Neighboring gene Protein phosphatase 1 regulatory subunit SDS22 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in Caenorhabditis elegans. Saltzman AL, et al. Genetics, 2018 Nov. PMID 30185429, Free PMC Article
  2. Mutation of C. elegans demethylase spr-5 extends transgenerational longevity. Greer EL, et al. Cell Res, 2016 Feb. PMID 26691751, Free PMC Article
  3. Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegans. Zheng C, et al. PLoS Genet, 2013. PMID 24348272, Free PMC Article
  4. Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos. Gonzalez-Sandoval A, et al. Cell, 2015 Dec 3. PMID 26607792
  5. A histone methylation network regulates transgenerational epigenetic memory in C. elegans. Greer EL, et al. Cell Rep, 2014 Apr 10. PMID 24685137, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in pericentric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Chromo domain-containing protein cec-3
NP_495652.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7855810..7857600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063251.8 → NP_495652.1  Chromo domain-containing protein cec-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495652.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P45968
    Conserved Domains (1) summary
    pfam00385
    Location:25 → 75
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45968.1

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