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wrt-1 Warthog protein 1 N-product [ Caenorhabditis elegans ]

Gene ID: 174223, updated on 2-Nov-2024

Summary

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Official Symbol
wrt-1
Official Full Name
Warthog protein 1 N-product
Primary source
WormBase:WBGene00006947
Locus tag
CELE_ZK1290.12
See related
AllianceGenome:WB:WBGene00006947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptidase activity. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in cell surface; extracellular region; and plasma membrane. Predicted to be active in extracellular matrix. Is expressed in hyp10; hyp6; hyp7 syncytium; hyp8; and hyp9. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wrt-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (7530996..7533246)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative oxidoreductase ZK1290.5 Neighboring gene WaRThog (hedgehog-like family) Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Porter JA, et al. Cell, 1996 Jul 12. PMID 8689684
  2. Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues. Gerisch B, et al. Development, 2004 Apr. PMID 15084461
  3. Warthog and groundhog, novel families related to hedgehog. Bürglin TR. Curr Biol, 1996 Sep 1. PMID 8805384
  4. Homologs of the Hh signalling network in C. elegans. Bürglin TR, et al. WormBook, 2006 Jan 28. PMID 18050469, Free PMC Article
  5. Hedgehog receptors exert immune-surveillance roles in the epidermis across species. Wang Q, et al. Cell Rep, 2023 Aug 29. PMID 37527037

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell-cell signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nematode male tail mating organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autoprocessing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in segment polarity determination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Warthog protein 1 N-product
NP_495579.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7530996..7533246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063178.8 → NP_495579.3  Warthog protein 1 N-product [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495579.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94128
    Conserved Domains (1) summary
    cd00081
    Location:290 → 428
    Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
Nucleotide Protein
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