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farl-11 DUF3402 domain-containing protein;Far11/STRP C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174165, updated on 4-Jan-2025

Summary

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Official Symbol
farl-11
Official Full Name
DUF3402 domain-containing protein;Far11/STRP C-terminal domain-containing protein
Primary source
WormBase:WBGene00017349
Locus tag
CELE_F10E7.8
See related
AllianceGenome:WB:WBGene00017349
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in endoplasmic reticulum organization; epithelial tube morphogenesis; and positive regulation of endocytic recycling. Located in endoplasmic reticulum. Is expressed in germ line. Orthologous to human STRIP1 (striatin interacting protein 1) and STRIP2 (striatin interacting protein 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See farl-11 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (7101218..7105035, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Methylmalonic aciduria type A homolog, mitochondrial Neighboring gene Large ribosomal subunit protein eL33 Neighboring gene Amino acid permease/ SLC12A domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FARL-11 (STRIP1/2) is required for sarcomere and sarcoplasmic reticulum organization in C. elegans. Martin SCT, et al. Mol Biol Cell, 2023 Aug 1. PMID 37314837, Free PMC Article
  2. A role for post-transcriptional control of endoplasmic reticulum dynamics and function in C. elegans germline stem cell maintenance. Maheshwari R, et al. Development, 2016 Sep 1. PMID 27510976, Free PMC Article
  3. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Lant B, et al. Nat Commun, 2015 Mar 6. PMID 25743393
  4. STRIPAK regulation of katanin microtubule severing in the Caenorhabditis elegans embryo. Lu T, et al. Genetics, 2022 May 5. PMID 35298637, Free PMC Article
  5. CCM-3 Promotes C. elegans Germline Development by Regulating Vesicle Trafficking Cytokinesis and Polarity. Pal S, et al. Curr Biol, 2017 Mar 20. PMID 28285997

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FARL-11 (STRIP1/2) is required for sarcomere and sarcoplasmic reticulum organization in C. elegans.
    Title: FARL-11 (STRIP1/2) is required for sarcomere and sarcoplasmic reticulum organization in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DUF3402 domain-containing protein;Far11/STRP C-terminal domain-containing protein
NP_001333549.1
  • Confirmed by transcript evidence
NP_001333550.1
  • Confirmed by transcript evidence
NP_495467.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7101218..7105035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346630.2 → NP_001333549.1  DUF3402 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1D3PCL0
    Conserved Domains (2) summary
    pfam07923
    Location:77 → 405
    N1221; N1221-like protein
    pfam11882
    Location:553 → 924
    DUF3402; Domain of unknown function (DUF3402)

  2. NM_063066.9 → NP_495467.2  DUF3402 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495467.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19300
    Conserved Domains (2) summary
    pfam07923
    Location:75 → 403
    N1221; N1221-like protein
    pfam11882
    Location:551 → 922
    DUF3402; Domain of unknown function (DUF3402)

  3. NM_001346631.3 → NP_001333550.1  Far11/STRP C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1D3PD01
    Conserved Domains (1) summary
    pfam11882
    Location:2 → 122
    DUF3402; Domain of unknown function (DUF3402)
Nucleotide Protein
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