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T19D12.4 VWFA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174096, updated on 2-Nov-2024

Summary

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Official Symbol
T19D12.4
Official Full Name
VWFA domain-containing protein
Primary source
WormBase:WBGene00020579
Locus tag
CELE_T19D12.4
See related
AllianceGenome:WB:WBGene00020579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in defense response to Gram-negative bacterium and innate immune response. Located in membrane raft. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T19D12.4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
12
Sequence:
Chromosome: II; NC_003280.10 (6631105..6637098)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Protein kinase domain-containing protein Neighboring gene non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Laminin G domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894
  2. Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor. Bar DZ, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27457958, Free PMC Article
  3. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
  4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response HEP PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft HDA PubMed 

General protein information

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Preferred Names
VWFA domain-containing protein
NP_001360065.1
  • Confirmed by transcript evidence
NP_001367890.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6631105..6637098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373732.1 → NP_001360065.1  VWFA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76836
    Conserved Domains (1) summary
    pfam00092
    Location:389 → 559
    VWA; von Willebrand factor type A domain

  2. NM_001381458.1 → NP_001367890.1  VWFA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2V4T0
    Conserved Domains (1) summary
    cd01450
    Location:375 → 534
    vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein
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