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aipr-1 TPR_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174092, updated on 9-Dec-2024

Summary

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Official Symbol
aipr-1
Official Full Name
TPR_REGION domain-containing protein
Primary source
WormBase:WBGene00016966
Locus tag
CELE_C56C10.10
See related
AllianceGenome:WB:WBGene00016966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Is expressed in several structures, including amphid sheath cell; dorsal nerve cord; neurons; oocyte; and spermatheca. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 4; blindness; pituitary adenoma 1; and retinitis pigmentosa. Orthologous to several human genes including AIP (aryl hydrocarbon receptor interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aipr-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (6592440..6594251, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Charged multivesicular body protein 4b Neighboring gene 45 kDa calcium-binding protein Neighboring gene DnaJ homolog subfamily C member 16;Thioredoxin domain-containing protein Neighboring gene Ectopic P granules protein 5 Neighboring gene Vacuolar protein sorting-associated protein 33B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor. Chen B, et al. Nat Commun, 2017 Nov 9. PMID 29123133, Free PMC Article
  2. Hsp90 in non-mammalian metazoan model systems. Haslbeck V, et al. Biochim Biophys Acta, 2012 Mar. PMID 21983200
  3. Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing. Jaramillo-Lambert A, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740937, Free PMC Article
  4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AIPR-1 is a potent inhibitor of synaptic transmission.AIPR-1 is a critical regulator of neurotransmitter release.
    Title: AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TPR_REGION domain-containing protein
NP_495339.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6592440..6594251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062938.6 → NP_495339.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495339.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18888
    Conserved Domains (3) summary
    sd00006
    Location:191 → 237
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:191 → 218
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:192 → 271
    TPR_11; TPR repeat
Nucleotide Protein
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