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snr-3 putative small nuclear ribonucleoprotein Sm D1;snRNP core protein D1 [ Caenorhabditis elegans ]

Gene ID: 174072, updated on 9-Dec-2024

Summary

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Official Symbol
snr-3
Official Full Name
putative small nuclear ribonucleoprotein Sm D1;snRNP core protein D1
Primary source
WormBase:WBGene00004916
Locus tag
CELE_T28D9.10
See related
AllianceGenome:WB:WBGene00004916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Located in P granule. Is expressed in gonad. Human ortholog(s) of this gene implicated in connective tissue disease; nephritis; proteinuria; and systemic lupus erythematosus. Orthologous to human SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See snr-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (6488830..6489761, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative lin-8 family protein lido-16 Neighboring gene Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein;Phospholipid phosphatase homolog 1.2 homolog Neighboring gene putative splicing factor, arginine/serine-rich 5 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel function for the Sm proteins in germ granule localization during C. elegans embryogenesis. Barbee SA, et al. Curr Biol, 2002 Sep 3. PMID 12225665
  2. PUF-8 and TCER-1 are essential for normal levels of multiple mRNAs in the C. elegans germline. Pushpa K, et al. Development, 2013 Mar. PMID 23444359, Free PMC Article
  3. RG/RGG repeats in the C. elegans homologs of Nucleolin and GAR1 contribute to sub-nucleolar phase separation. Spaulding EL, et al. Nat Commun, 2022 Nov 3. PMID 36329008, Free PMC Article
  4. RSR-2, the Caenorhabditis elegans ortholog of human spliceosomal component SRm300/SRRM2, regulates development by influencing the transcriptional machinery. Fontrodona L, et al. PLoS Genet, 2013 Jun. PMID 23754964, Free PMC Article
  5. The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling. Rüegger S, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25753661, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SMN-Sm protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of commitment complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of pICln-Sm protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative small nuclear ribonucleoprotein Sm D1;snRNP core protein D1
NP_001317766.1
  • Confirmed by transcript evidence
NP_495306.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6488830..6489761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330951.3 → NP_001317766.1  snRNP core protein D1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    M1ZJ32
    Conserved Domains (1) summary
    cl00259
    Location:1 → 59
    Sm_like; Sm and related proteins

  2. NM_062905.8 → NP_495306.1  putative small nuclear ribonucleoprotein Sm D1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495306.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10013
    Conserved Domains (1) summary
    cd01724
    Location:2 → 88
    Sm_D1; Sm protein D1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10013.1

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