atg-16.2 Autophagic-related protein 16.2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atg-16.2
Official Full Name: Autophagic-related protein 16.2
Primary source: WormBase:WBGene00019427
Locus tag: CELE_K06A1.5
See related: AllianceGenome:WB:WBGene00019427
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein-membrane adaptor activity. Involved in several processes, including defense response to Gram-positive bacterium; germ cell proliferation; and macroautophagy. Located in cytoplasm. Is expressed in body wall musculature; embryonic cell; intestine; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Orthologous to human ATG16L1 (autophagy related 16 like 1) and ATG16L2 (autophagy related 16 like 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See atg-16.2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (6450889..6453391, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C. elegans ATG-16s are involved in specifying LGG-1 puncta formation; the two ATG-16 homologs have partially redundant yet distinct functions in the aggrephagy pathway.
Title: The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K06A1.5 (e-PCR)
- UniSTS:311429

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in aggrephagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in aggrephagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Atg12-Atg5-Atg16 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Autophagic-related protein 16.2

NP_495299.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6450889..6453391 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062898.4 → NP_495299.2 Autophagic-related protein 16.2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495299.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09406

Conserved Domains (5) summary

COG2319
Location:231 → 499

WD40; WD40 repeat [General function prediction only]

cd00200
Location:241 → 524

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08614
Location:11 → 181

ATG16; Autophagy protein 16 (ATG16)

sd00039
Location:294 → 330

7WD40; WD40 repeat [structural motif]

cl11531
Location:107 → 175

DUF904; Protein of unknown function (DUF904)