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spp-11 Leguminosin group485 secreted peptide;Saposin B-type domain-containing protein;Saposin-like protein 11 [ Caenorhabditis elegans ]

Gene ID: 174063, updated on 4-Jan-2025

Summary

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Official Symbol
spp-11
Official Full Name
Leguminosin group485 secreted peptide;Saposin B-type domain-containing protein;Saposin-like protein 11
Primary source
WormBase:WBGene00004996
Locus tag
CELE_T25D10.3
See related
AllianceGenome:WB:WBGene00004996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Orthologous to human PRX (periaxin). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See spp-11 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (6405388..6407379, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Nicholas HR, et al. Mol Immunol, 2004 Jul. PMID 15183927
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

General protein information

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Preferred Names
Leguminosin group485 secreted peptide;Saposin B-type domain-containing protein;Saposin-like protein 11
NP_001352251.1
  • Confirmed by transcript evidence
NP_001355419.1
  • Confirmed by transcript evidence
NP_001355420.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6405388..6407379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001368591.4 → NP_001355419.1  Saposin B-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10018
    UniProtKB/TrEMBL
    A0A3B1E8S4
    Conserved Domains (2) summary
    PRK15370
    Location:74 → 291
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00741
    Location:298 → 383
    SapB; Saposin (B) Domains

  2. NM_001365320.2 → NP_001352251.1  Saposin-like protein 11 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    smart00741
    Location:160 → 245
    SapB; Saposin (B) Domains

  3. NM_001368592.3 → NP_001355420.1  Leguminosin group485 secreted peptide [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1DQA9
Nucleotide Protein
Heading Accession and Version

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