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ctsa-4.1 Serine carboxypeptidase ctsa-4.1 [ Caenorhabditis elegans ]

Gene ID: 174057, updated on 4-Jan-2025

Summary

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Official Symbol
ctsa-4.1
Official Full Name
Serine carboxypeptidase ctsa-4.1
Primary source
WormBase:WBGene00019605
Locus tag
CELE_K10B2.2
See related
AllianceGenome:WB:WBGene00019605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ctsa-4.1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (6366996..6369091)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein Asterix Neighboring gene Anillin-like protein 2 Neighboring gene C-type lectin domain-containing protein;C-type lectin domain-containing protein 88 Neighboring gene ncRNA Neighboring gene F-box domain-containing protein;F-box/WD repeat-containing protein lin-23

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans. Ludewig AH, et al. Genes Nutr, 2014 Jan. PMID 24311442, Free PMC Article
  2. Sexual dimorphism in Caenorhabditis elegans stress resistance. Piloto JH, et al. PLoS One, 2022. PMID 35951614, Free PMC Article
  3. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress. Li TY, et al. Nat Aging, 2021 Feb. PMID 33718883, Free PMC Article
  4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  5. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serine carboxypeptidase ctsa-4.1
NP_001379755.1
  • Confirmed by transcript evidence
NP_495284.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6366996..6369091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062883.8 → NP_495284.1  Serine carboxypeptidase ctsa-4.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495284.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09991, Q86NG2
    Conserved Domains (1) summary
    pfam00450
    Location:30 → 460
    Peptidase_S10; Serine carboxypeptidase

  2. NM_001393099.1 → NP_001379755.1  Serine carboxypeptidase ctsa-4.1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl08270
    Location:1 → 194
    Peptidase_S10; Serine carboxypeptidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09991.1

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