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T24H7.2 Hypoxia up-regulated protein 1 [ Caenorhabditis elegans ]

Gene ID: 174033, updated on 2-Nov-2024

Summary

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Official Symbol
T24H7.2
Official Full Name
Hypoxia up-regulated protein 1
Primary source
WormBase:WBGene00020781
Locus tag
CELE_T24H7.2
See related
AllianceGenome:WB:WBGene00020781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable adenyl-nucleotide exchange factor activity. Involved in IRE1-mediated unfolded protein response. Predicted to be part of endoplasmic reticulum chaperone complex. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T24H7.2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (6247311..6250844)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 4 Neighboring gene GSKIP domain-containing protein Neighboring gene ncRNA Neighboring gene Mitochondrial prohibitin complex protein 2 Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene Lipase_GDSL domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Hypoxia up-regulated protein 1
NP_495249.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6247311..6250844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062848.6 → NP_495249.1  Hypoxia up-regulated protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495249.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22758
    Conserved Domains (2) summary
    cd10230
    Location:27 → 413
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    COG0443
    Location:29 → 669
    DnaK; Molecular chaperone DnaK (HSP70) [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version

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