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abts-3 Bicarbonate transporter-like transmembrane domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174024, updated on 4-Jan-2025

Summary

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Official Symbol
abts-3
Official Full Name
Bicarbonate transporter-like transmembrane domain-containing protein
Primary source
WormBase:WBGene00019018
Locus tag
CELE_F57F10.1
See related
AllianceGenome:WB:WBGene00019018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic ion homeostasis and transmembrane transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in hypodermis and neurons. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; congenital hereditary endothelial dystrophy of cornea; and corneal dystrophy-perceptive deafness syndrome. Orthologous to human SLC4A11 (solute carrier family 4 member 11). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See abts-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
20
Sequence:
Chromosome: II; NC_003280.10 (6132895..6157184)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene arginine--tRNA ligase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Gamma-aminobutyric acid receptor exp-1 Neighboring gene ncRNA Neighboring gene Sulfotransferase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The abts and sulp families of anion transporters from Caenorhabditis elegans. Sherman T, et al. Am J Physiol Cell Physiol, 2005 Aug. PMID 15814591
  2. Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development. Zheleva A, et al. PLoS Genet, 2019 Sep. PMID 31525188, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in borate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bicarbonate transporter-like transmembrane domain-containing protein
NP_001355398.1
  • Partially confirmed by transcript evidence
NP_001355414.1
  • Confirmed by transcript evidence
NP_001367590.1
  • Confirmed by transcript evidence
NP_001367591.1
  • Confirmed by transcript evidence
NP_495228.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6132895..6157184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001368589.3 → NP_001355398.1  Bicarbonate transporter-like transmembrane domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E4W4
    Conserved Domains (2) summary
    COG1762
    Location:133 → 294
    PtsN; Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms]
    pfam00955
    Location:334 → 824
    HCO3_cotransp; HCO3- transporter family

  2. NM_001381448.2 → NP_001367590.1  Bicarbonate transporter-like transmembrane domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQ15
    Conserved Domains (1) summary
    pfam00955
    Location:253 → 743
    HCO3_cotransp; HCO3- transporter family

  3. NM_001381447.1 → NP_001367591.1  Bicarbonate transporter-like transmembrane domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4S481, Q3Y415
    Conserved Domains (1) summary
    pfam00955
    Location:346 → 836
    HCO3_cotransp; HCO3- transporter family

  4. NM_001368590.4 → NP_001355414.1  Bicarbonate transporter-like transmembrane domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E616
    Conserved Domains (2) summary
    COG1762
    Location:298 → 459
    PtsN; Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms]
    pfam00955
    Location:499 → 989
    HCO3_cotransp; HCO3- transporter family

  5. NM_062827.6 → NP_495228.1  Bicarbonate transporter-like transmembrane domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495228.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBE4
    Conserved Domains (2) summary
    COG1762
    Location:214 → 375
    PtsN; Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms]
    pfam00955
    Location:415 → 905
    HCO3_cotransp; HCO3- transporter family
Nucleotide Protein
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