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acdh-8 medium-chain acyl-CoA dehydrogenase [ Caenorhabditis elegans ]

Gene ID: 173979, updated on 2-Nov-2024

Summary

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Official Symbol
acdh-8
Official Full Name
medium-chain acyl-CoA dehydrogenase
Primary source
WormBase:WBGene00019406
Locus tag
CELE_K05F1.3
See related
AllianceGenome:WB:WBGene00019406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable medium-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in medium-chain fatty acid catabolic process. Predicted to be active in mitochondrion. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acdh-8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (5794495..5796185)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Leukocyte cell-derived chemotaxin-2 homolog Neighboring gene Uncharacterized protein Neighboring gene Major sperm protein 63 Neighboring gene Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pasteurized Akkermansia muciniphila Reduces Fat Accumulation via nhr-49-Mediated Nuclear Hormone Signaling Pathway in Caenorhabditis elegans. Wu Z, et al. Molecules, 2022 Sep 20. PMID 36234692, Free PMC Article
  2. A bioinformatics approach to elucidate conserved genes and pathways in C. elegans as an animal model for cardiovascular research. Ray AK, et al. Sci Rep, 2024 Mar 29. PMID 38553458, Free PMC Article
  3. Evaluating the adverse effects and mechanisms of nanomaterial exposure on longevity of C. elegans: A literature meta-analysis and bioinformatics analysis of multi-transcriptome data. Yin F, et al. Environ Res, 2024 Apr 15. PMID 38224941
  4. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
  5. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables medium-chain fatty acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in medium-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
medium-chain acyl-CoA dehydrogenase
NP_495142.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5794495..5796185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062741.7 → NP_495142.1  medium-chain acyl-CoA dehydrogenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495142.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21243
    Conserved Domains (2) summary
    COG1960
    Location:21 → 400
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
    cl09933
    Location:25 → 400
    ACAD; Acyl-CoA dehydrogenase
Nucleotide Protein
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