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gcy-12 Receptor-type guanylate cyclase gcy-12 [ Caenorhabditis elegans ]

Gene ID: 173902, updated on 4-Jan-2025

Summary

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Official Symbol
gcy-12
Official Full Name
Receptor-type guanylate cyclase gcy-12
Primary source
WormBase:WBGene00001538
Locus tag
CELE_F08B1.2
See related
AllianceGenome:WB:WBGene00001538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables guanylate cyclase activity. Involved in negative regulation of dauer larval development; regulation of growth; and regulation of locomotion involved in locomotory behavior. Located in dendrite; non-motile cilium; and perikaryon. Is expressed in excretory gland cell; ganglia; head muscle; and head neurons. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See gcy-12 in Genome Data Viewer
Location:
chromosome: II
Exon count:
16
Sequence:
Chromosome: II; NC_003280.10 (5312046..5319617)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein kinase Neighboring gene ncRNA Neighboring gene Tyrosine-protein phosphatase vhp-1;protein-tyrosine-phosphatase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel zf-MYND protein, CHB-3, mediates guanylyl cyclase localization to sensory cilia and controls body size of Caenorhabditis elegans. Fujiwara M, et al. PLoS Genet, 2010 Nov 24. PMID 21124861, Free PMC Article
  2. The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans. Fujiwara M, et al. Genetics, 2015 Dec. PMID 26434723, Free PMC Article
  3. Identification of a spontaneously arising variant affecting thermotaxis behavior in a recombinant inbred Caenorhabditis elegans line. Yeon J, et al. G3 (Bethesda), 2023 Sep 30. PMID 37572357, Free PMC Article
  4. Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors. Yu S, et al. Proc Natl Acad Sci U S A, 1997 Apr 1. PMID 9096403, Free PMC Article
  5. Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans. Hallem EA, et al. Proc Natl Acad Sci U S A, 2011 Jan 4. PMID 21173231, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of locomotion involved in locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Receptor-type guanylate cyclase gcy-12
NP_494995.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5312046..5319617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062594.3 → NP_494995.2  Receptor-type guanylate cyclase gcy-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494995.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19187
    Conserved Domains (7) summary
    cd06370
    Location:123 → 545
    PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
    smart00219
    Location:688 → 951
    TyrKc; Tyrosine kinase, catalytic domain
    smart00044
    Location:991 → 1183
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:648 → 957
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:1018 → 1206
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:140 → 519
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:967 → 1012
    HNOBA; Heme NO binding associated

RNA

  1. NR_134556.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19187.3

Gene LinkOut

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