U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ify-1 Securin-like protein [ Caenorhabditis elegans ]

Gene ID: 173872, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
ify-1
Official Full Name
Securin-like protein
Primary source
WormBase:WBGene00002068
Locus tag
CELE_C27A2.3
See related
AllianceGenome:WB:WBGene00002068
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protease binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cortical granule exocytosis; nuclear division; and protein stabilization. Located in condensed chromosome; cytoplasm; and spindle microtubule. Is expressed in germ cell and germ line. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ify-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (5054135..5055179, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene PPM-type phosphatase domain-containing protein Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein eL22 Neighboring gene Histidine acid phosphatase Neighboring gene ncRNA Neighboring gene tRNA-Ile

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution. Boland A, et al. Nat Struct Mol Biol, 2017 Apr. PMID 28263324, Free PMC Article
  2. A closed conformation of the Caenorhabditis elegans separase-securin complex. Bachmann G, et al. Open Biol, 2016 Apr. PMID 27249343, Free PMC Article
  3. Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans. Tarailo M, et al. Genetics, 2007 Apr. PMID 17237515, Free PMC Article
  4. Taxonomically Restricted Genes with Essential Functions Frequently Play Roles in Chromosome Segregation in Caenorhabditis elegans and Saccharomyces cerevisiae. Verster AJ, et al. G3 (Bethesda), 2017 Oct 5. PMID 28839119, Free PMC Article
  5. HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans. Wang R, et al. Development, 2013 May. PMID 23578927

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBC-18 plays a distinct role together with ETC-1 in regulating the cytoplasmic level of IFY-1 during meiosis in C. elegans
    Title: HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical granule exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polar body extrusion after meiotic divisions IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Securin-like protein
NP_494931.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5054135..5055179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062530.11 → NP_494931.1  Securin-like protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494931.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18235
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18235.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools