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ipla-1 Intracellular phospholipase A1 [ Caenorhabditis elegans ]

Gene ID: 173795, updated on 4-Jan-2025

Summary

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Official Symbol
ipla-1
Official Full Name
Intracellular phospholipase A1
Primary source
WormBase:WBGene00019747
Locus tag
CELE_M03A1.6
See related
AllianceGenome:WB:WBGene00019747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables identical protein binding activity; phospholipase activity; and phospholipid binding activity. Involved in glycerophospholipid metabolic process; regulation of asymmetric cell division; and regulation of protein localization. Located in cytosol; endoplasmic reticulum; and nucleus. Part of phosphatase complex. Is expressed in several structures, including arcade cell; excretory cell; pharyngeal-intestinal valve; rectum; and reproductive system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 28. Orthologous to human DDHD1 (DDHD domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ipla-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
12
Sequence:
Chromosome: II; NC_003280.10 (4590939..4601356, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene ncRNA Neighboring gene Ephrin receptor 1 Neighboring gene Cytochrome c oxidase assembly factor 3 Neighboring gene CYTH domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism. Chen TL, et al. Cell Death Dis, 2017 Jan 12. PMID 28079896, Free PMC Article
  2. Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol. Imae R, et al. Mol Biol Cell, 2010 Sep 15. PMID 20668164, Free PMC Article
  3. Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling. Schmeisser S, et al. Cell Rep, 2019 Dec 24. PMID 31875559
  4. Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform. Morrison K, et al. J Biol Chem, 2012 Nov 9. PMID 23007400, Free PMC Article
  5. Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions. Kanamori T, et al. EMBO J, 2008 Jun 18. PMID 18497747, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abnormal glycerophospholipid metabolism leading to defective embryonic development could be attributed to the increased activity of calcium-independent phospholipase A2 (iPLA) in G6PD-deficient embryos. This notion is further supported by the fact that the suppression of multiple iPLAs by genetic manipulation partially rescued the embryonic defects in G6PD-deficient embryos.
    Title: Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism.
  2. membrane composition and the presence of nucleotides play key roles in recruiting and modulating GVIA-iPLA(2) activity in cells
    Title: Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform.
  3. Study identified acl-8, -9, and -10, which are closely related to each other, and ipla-1 as strong candidates for genes involved in fatty acid remodeling at the sn-1 position of phosphatidylinositol.
    Title: Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium-independent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase A1 activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphatase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Intracellular phospholipase A1
NP_001040793.1
  • Confirmed by transcript evidence
NP_001040794.1
  • Confirmed by transcript evidence
NP_001300574.1
  • Confirmed by transcript evidence
NP_001367816.1
  • Confirmed by transcript evidence
NP_001367817.1
  • Confirmed by transcript evidence
NP_740976.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4590939..4601356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170979.6 → NP_740976.1  Intracellular phospholipase A1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740976.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21478
    Conserved Domains (1) summary
    pfam02862
    Location:492 → 751
    DDHD; DDHD domain

  2. NM_001381395.3 → NP_001367816.1  Intracellular phospholipase A1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam02862
    Location:480 → 739
    DDHD; DDHD domain

  3. NM_001381394.1 → NP_001367817.1  Intracellular phospholipase A1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AU10, G4SGS5, G4SGU1, G5EE61, G5EEM9, G8JYA8, Q21478, Q8WQE0
    Conserved Domains (1) summary
    pfam02862
    Location:567 → 826
    DDHD; DDHD domain

  4. NM_001047329.4 → NP_001040794.1  Intracellular phospholipase A1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040794.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G8JYA8
    Conserved Domains (1) summary
    pfam02862
    Location:504 → 763
    DDHD; DDHD domain

  5. NM_001047328.5 → NP_001040793.1  Intracellular phospholipase A1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040793.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SGU1
    Conserved Domains (1) summary
    pfam02862
    Location:506 → 765
    DDHD; DDHD domain

  6. NM_001313645.3 → NP_001300574.1  Intracellular phospholipase A1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU10
    Conserved Domains (1) summary
    pfam02862
    Location:395 → 654
    DDHD; DDHD domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EEM9.1

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