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camt-1 Calmodulin-binding transcription activator homolog 1 [ Caenorhabditis elegans ]

Gene ID: 173786, updated on 9-Dec-2024

Summary

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Official Symbol
camt-1
Official Full Name
Calmodulin-binding transcription activator homolog 1
Primary source
WormBase:WBGene00020251
Locus tag
CELE_T05C1.4
See related
AllianceGenome:WB:WBGene00020251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables chromatin binding activity. Involved in positive chemotaxis; positive regulation of transcription by RNA polymerase II; and response to oxygen levels. Located in chromatin and nucleus. Human ortholog(s) of this gene implicated in nonprogressive cerebellar ataxia with mental retardation. Orthologous to several human genes including CAMTA2 (calmodulin binding transcription activator 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See camt-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
19
Sequence:
Chromosome: II; NC_003280.10 (4491152..4505147, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene Myoblast determination protein 1 homolog Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuronal calmodulin levels are controlled by CAMTA transcription factors. Vuong-Brender TT, et al. Elife, 2021 Sep 9. PMID 34499028, Free PMC Article
  2. An actin-based viscoplastic lock ensures progressive body-axis elongation. Lardennois A, et al. Nature, 2019 Sep. PMID 31462781, Free PMC Article
  3. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
  4. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
  5. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of macromolecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of primary metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxygen levels IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Calmodulin-binding transcription activator homolog 1
NP_001022314.1
  • Confirmed by transcript evidence
NP_494795.2
  • Partially confirmed by transcript evidence
NP_494796.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4491152..4505147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062395.3 → NP_494796.2  Calmodulin-binding transcription activator homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494796.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KY85
    Conserved Domains (6) summary
    smart00015
    Location:982 → 1003
    IQ; Calmodulin-binding motif
    smart01076
    Location:76 → 195
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00102
    Location:415 → 499
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cd00204
    Location:577 → 654
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:580 → 658
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:616 → 648
    ANK; ANK repeat [structural motif]

  2. NM_062394.5 → NP_494795.2  Calmodulin-binding transcription activator homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494795.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KY84, H2KY85, Q629J3
    Conserved Domains (6) summary
    smart00015
    Location:982 → 1003
    IQ; Calmodulin-binding motif
    smart01076
    Location:76 → 195
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00102
    Location:415 → 499
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cd00204
    Location:577 → 654
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:580 → 658
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:616 → 648
    ANK; ANK repeat [structural motif]

  3. NM_001027143.6 → NP_001022314.1  Calmodulin-binding transcription activator homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022314.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q629J3
Nucleotide Protein
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