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sod-5 Superoxide dismutase [Cu-Zn] [ Caenorhabditis elegans ]

Gene ID: 173776, updated on 4-Jan-2025

Summary

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Official Symbol
sod-5
Official Full Name
Superoxide dismutase [Cu-Zn]
Primary source
WormBase:WBGene00007036
Locus tag
CELE_ZK430.3
See related
AllianceGenome:WB:WBGene00007036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable copper ion binding activity and superoxide dismutase activity. Predicted to be involved in removal of superoxide radicals. Is expressed in amphid neurons. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Orthologous to several human genes including SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sod-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (4417633..4419130)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Peroxidase mlt-7 light chain Neighboring gene separase Neighboring gene 3'(2'),5'-bisphosphate nucleotidase 1 Neighboring gene DDB1- and CUL4-associated factor 13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Daily rhythm of gene expression in rat superoxide dismutases. Martín V, et al. Endocr Res, 2003 Feb. PMID 12665321
  2. Toxic effects of prolonged exposure to [C(14)mim]Br on Caenorhabditis elegans. Peng Y, et al. Chemosphere, 2018 Oct. PMID 29879555
  3. Hormetic effect and mechanism of imidazolium-based ionic liquids on the nematode Caenorhabditis elegans. Zhu CJ, et al. Chemosphere, 2016 Aug. PMID 27209554
  4. Activation of CuZn superoxide dismutases from Caenorhabditis elegans does not require the copper chaperone CCS. Jensen LT, et al. J Biol Chem, 2005 Dec 16. PMID 16234242
  5. Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans. Dues DJ, et al. Free Radic Biol Med, 2017 Jul. PMID 28392283, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables superoxide dismutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Superoxide dismutase [Cu-Zn]
NP_494779.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4417633..4419130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062378.6 → NP_494779.1  Superoxide dismutase [Cu-Zn] [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494779.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q27538
    Conserved Domains (1) summary
    pfam00080
    Location:33 → 172
    Sod_Cu; Copper/zinc superoxide dismutase (SODC)
Nucleotide Protein
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