cpna-1 Copine family protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cpna-1
Official Full Name: Copine family protein 1
Primary source: WormBase:WBGene00006495
Locus tag: CELE_F31D5.3
See related: AllianceGenome:WB:WBGene00006495
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables phosphatase binding activity and protein-macromolecule adaptor activity. Involved in positive regulation of sarcomere organization. Located in M band and striated muscle dense body. Is expressed in body wall musculature. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cpna-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (4186664..4208500)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We propose that CPNA-1 acts as a linker between an integrin-associated protein, PAT-6, and membrane-distal components of integrin adhesion complexes in the muscle of C. elegans.
Title: CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F31D5.3 (e-PCR)
- UniSTS:310046

F31D5.4 (e-PCR)
- UniSTS:310047

F31D5.5 (e-PCR)
- UniSTS:306210

STS2-130 (e-PCR)
- UniSTS:241797

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Copine family protein 1

NP_494736.1

Confirmed by transcript evidence

NP_494737.1

Confirmed by transcript evidence

NP_871985.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4186664..4208500

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_182185.6 → NP_871985.1 Copine family protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871985.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2KYS8
NM_062336.6 → NP_494737.1 Copine family protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494737.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2KYS8

Conserved Domains (1) summary

cl00057
Location:837 → 1062

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_062335.8 → NP_494736.1 Copine family protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494736.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2KYS8, H2KYS9, H2KYT0, Q7JPE2

Conserved Domains (1) summary

cl00057
Location:853 → 1078

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...