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skr-15 Skp1-related protein [ Caenorhabditis elegans ]

Gene ID: 173729, updated on 4-Jan-2025

Summary

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Official Symbol
skr-15
Official Full Name
Skp1-related protein
Primary source
WormBase:WBGene00004821
Locus tag
CELE_F54D10.1
See related
AllianceGenome:WB:WBGene00004821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See skr-15 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003280.10 (3824155..3824709)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DUF38 domain-containing protein Neighboring gene Ubiquitin-like domain-containing protein Neighboring gene Glycosyltransferase family 92 protein Neighboring gene Sushi domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age. Fielenbach N, et al. Dev Cell, 2007 Mar. PMID 17336909
  2. Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Ghazi A, et al. Proc Natl Acad Sci U S A, 2007 Apr 3. PMID 17392428, Free PMC Article
  3. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Pothof J, et al. Genes Dev, 2003 Feb 15. PMID 12600937, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Skp1-related protein
NP_494662.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    3824155..3824709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062261.7 → NP_494662.1  Skp1-related protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494662.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE88
    Conserved Domains (3) summary
    smart00512
    Location:20 → 127
    Skp1; Found in Skp1 protein family
    COG5201
    Location:23 → 176
    SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
    pfam01466
    Location:101 → 167
    Skp1; Skp1 family, dimerization domain
Nucleotide Protein
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