skpo-2 ShKT domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: skpo-2
Official Full Name: ShKT domain-containing protein
Primary source: WormBase:WBGene00015841
Locus tag: CELE_C16C8.2
See related: AllianceGenome:WB:WBGene00015841
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See skpo-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 14

Sequence:: Chromosome: II; NC_003280.10 (3431282..3436512, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS2-30 (e-PCR)
- UniSTS:241928

C16C8.2 (e-PCR)
- UniSTS:308579

C16C8.3 (e-PCR)
- UniSTS:317876

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	RCA inferred from Reviewed Computational Analysis more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ShKT domain-containing protein

NP_494540.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

3431282..3436512 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062139.8 → NP_494540.1 ShKT domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494540.1

Status: REVIEWED

UniProtKB/TrEMBL

P91060

Conserved Domains (3) summary

cd09823
Location:341 → 687

peroxinectin_like; peroxinectin_like animal heme peroxidases

smart00254
Location:61 → 95

ShKT; ShK toxin domain

pfam03098
Location:204 → 690

An_peroxidase; Animal haem peroxidase