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K12H6.6 TLC domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173629, updated on 9-Dec-2024

Summary

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Official Symbol
K12H6.6
Official Full Name
TLC domain-containing protein
Primary source
WormBase:WBGene00019686
Locus tag
CELE_K12H6.6
See related
AllianceGenome:WB:WBGene00019686
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including TLCD2 (TLC domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See K12H6.6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (2828577..2831233, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene DsbC domain-containing protein Neighboring gene DsbC domain-containing protein Neighboring gene FBA_2 domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane lipid distribution IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TLC domain-containing protein
NP_494378.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2828577..2831233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061977.5 → NP_494378.1  TLC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494378.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N5G9
    Conserved Domains (1) summary
    smart00724
    Location:76 → 269
    TLC; TRAM, LAG1 and CLN8 homology domains

RNA

  1. NR_149262.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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