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tsr-1 Xpo1 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173601, updated on 9-Dec-2024

Summary

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Official Symbol
tsr-1
Official Full Name
Xpo1 domain-containing protein
Primary source
WormBase:WBGene00006647
Locus tag
CELE_F53G2.6
See related
AllianceGenome:WB:WBGene00006647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 2. Orthologous to human TNPO3 (transportin 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tsr-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
16
Sequence:
Chromosome: II; NC_003280.10 (2460842..2473370, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CDK-activating kinase assembly factor MAT1 Neighboring gene Complex 1 LYR protein domain-containing protein;Complex1_LYR_dom domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Quan Y, et al. Mol Cell Proteomics, 2008 Jul. PMID 18353765, Free PMC Article
  2. Functional characterization of SR and SR-related genes in Caenorhabditis elegans. Longman D, et al. EMBO J, 2000 Apr 3. PMID 10747030, Free PMC Article
  3. AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans. Pispa J, et al. iScience, 2023 Oct 20. PMID 37767001, Free PMC Article
  4. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
  5. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Xpo1 domain-containing protein
NP_001368720.1
  • Confirmed by transcript evidence
NP_001370995.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2460842..2473370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383801.1 → NP_001370995.1  Xpo1 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3P6NNQ0
    Conserved Domains (1) summary
    pfam08389
    Location:1 → 109
    Xpo1; Exportin 1-like protein

  2. NM_001381350.1 → NP_001368720.1  Xpo1 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3P6P962
    Conserved Domains (1) summary
    pfam08389
    Location:1 → 109
    Xpo1; Exportin 1-like protein
Nucleotide Protein
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