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gba-1 Putative glucosylceramidase 1 [ Caenorhabditis elegans ]

Gene ID: 173574, updated on 9-Dec-2024

Summary

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Official Symbol
gba-1
Official Full Name
Putative glucosylceramidase 1
Primary source
WormBase:WBGene00016335
Locus tag
CELE_C33C12.3
See related
AllianceGenome:WB:WBGene00016335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glucosylceramidase activity. Predicted to be involved in glucosylceramide catabolic process. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gba-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
13
Sequence:
Chromosome: II; NC_003280.10 (2176741..2182510)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene AMP-binding_C domain-containing protein Neighboring gene Putative glucosylceramidase 2 Neighboring gene Methyltransferase small domain-containing protein Neighboring gene Membralin;TMV resistance protein N-like Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reverse genetic screening during L1 arrest reveals a role of the diacylglycerol kinase 1 gene dgk-1 and sphingolipid metabolism genes in sleep regulation. Koutsoumparis A, et al. Genetics, 2023 Oct 4. PMID 37682641
  2. Analysis of Caenorhabditis elegans phosphoproteome reveals the involvement of a molecular chaperone, HSP-90 protein during Salmonella enterica Serovar Typhi infection. Balasubramaniam B, et al. Int J Biol Macromol, 2019 Sep 15. PMID 31252012
  3. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
  4. Improved Biocompatibility of Amino-Functionalized Graphene Oxide in Caenorhabditis elegans. Rive C, et al. Small, 2019 Nov. PMID 31576668
  5. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glucosylceramidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosylceramidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucosylceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Putative glucosylceramidase 1
NP_001040750.1
  • Confirmed by transcript evidence
NP_001040751.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2176741..2182510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047285.3 → NP_001040750.1  Putative glucosylceramidase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040750.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8DZ32, O16580
    Conserved Domains (1) summary
    pfam02055
    Location:23 → 519
    Glyco_hydro_30; O-Glycosyl hydrolase family 30

  2. NM_001047286.3 → NP_001040751.1  Putative glucosylceramidase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040751.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16580
    Conserved Domains (1) summary
    cl23815
    Location:1 → 466
    Glyco_hydro_30; O-Glycosyl hydrolase family 30
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16580.2

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