gldi-1 NLE domain-containing protein;WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gldi-1
Official Full Name: NLE domain-containing protein;WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00021074
Locus tag: CELE_W07E6.2
See related: AllianceGenome:WB:WBGene00021074
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in regulation of Notch signaling pathway. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See gldi-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (480721..484378, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W07E6.2 (e-PCR)
- UniSTS:315187

W07E6.4 (e-PCR)
- UniSTS:311154

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NLE domain-containing protein;WD_REPEATS_REGION domain-containing protein

NP_001303797.1

Confirmed by transcript evidence

NP_493745.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

480721..484378 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061344.5 → NP_493745.1 NLE domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493745.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9TYV3

Conserved Domains (4) summary

smart00320
Location:433 → 471

WD40; WD40 repeats

cd00200
Location:97 → 430

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:150 → 188

7WD40; WD40 repeat [structural motif]

pfam08154
Location:7 → 70

NLE; NLE (NUC135) domain
NM_001316868.3 → NP_001303797.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0M9JJ65

Conserved Domains (2) summary

sd00039
Location:22 → 58

7WD40; WD40 repeat [structural motif]

cl29593
Location:2 → 129

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...