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tre-5 Trehalase [ Caenorhabditis elegans ]

Gene ID: 173388, updated on 4-Jan-2025

Summary

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Official Symbol
tre-5
Official Full Name
Trehalase
Primary source
WormBase:WBGene00006611
Locus tag
CELE_C23H3.7
See related
AllianceGenome:WB:WBGene00006611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable alpha,alpha-trehalase activity. Predicted to be involved in trehalose catabolic process. Is expressed in head and hypodermis. Orthologous to human TREH (trehalase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tre-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (52997..55304, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative 26S proteasome regulatory subunit 10B Neighboring gene RNA polymerase I associated factor, A49-like protein Neighboring gene Nucleolus and neural progenitor protein-like N-terminal domain-containing protein Neighboring gene Serine palmitoyltransferase 1 Neighboring gene K Homology domain-containing protein Neighboring gene DUF3810 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes. Pellerone FI, et al. Int J Parasitol, 2003 Sep 30. PMID 13678635
  2. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
  3. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
  4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables alpha,alpha-trehalase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha,alpha-trehalase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in trehalose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in trehalose metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Trehalase
NP_493649.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    52997..55304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061248.5 → NP_493649.2  Trehalase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493649.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG96
    Conserved Domains (1) summary
    cl17346
    Location:96 → 605
    Trehalase; Trehalase
Nucleotide Protein
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