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ero-1 Endoplasmic oxidoreductin;Endoplasmic reticulum oxidoreductin-1 [ Caenorhabditis elegans ]

Gene ID: 173325, updated on 9-Dec-2024

Summary

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Official Symbol
ero-1
Official Full Name
Endoplasmic oxidoreductin;Endoplasmic reticulum oxidoreductin-1
Primary source
WormBase:WBGene00001334
Locus tag
CELE_Y105E8B.8
See related
AllianceGenome:WB:WBGene00001334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein-disulfide reductase activity. Involved in IRE1-mediated unfolded protein response and protein folding in endoplasmic reticulum. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ERO1A (endoplasmic reticulum oxidoreductase 1 alpha) and ERO1B (endoplasmic reticulum oxidoreductase 1 beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ero-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (14664449..14674841)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Hypoxanthine phosphoribosyltransferase Neighboring gene BZIP domain-containing protein Neighboring gene ncRNA Neighboring gene Beta-glucuronidase Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Harding HP, et al. Mol Cell, 2003 Mar. PMID 12667446
  2. Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response. Hourihan JM, et al. Mol Cell, 2016 Aug 18. PMID 27540856, Free PMC Article
  3. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Marciniak SJ, et al. Genes Dev, 2004 Dec 15. PMID 15601821, Free PMC Article
  4. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Ye Y, et al. Nature, 2004 Jun 24. PMID 15215856
  5. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. Yoneda T, et al. J Cell Sci, 2004 Aug 15. PMID 15280428

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiol oxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in IRE1-mediated unfolded protein response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in protein folding in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Endoplasmic oxidoreductin;Endoplasmic reticulum oxidoreductin-1
NP_001293161.1
  • Confirmed by transcript evidence
NP_001364626.1
  • Confirmed by transcript evidence
NP_001364632.1
  • Confirmed by transcript evidence
NP_001364667.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14664449..14674841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377681.1 → NP_001364626.1  Endoplasmic reticulum oxidoreductin-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7YTU4, Q95Q33
    Conserved Domains (1) summary
    pfam04137
    Location:54 → 445
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  2. NM_001377680.2 → NP_001364667.1  Endoplasmic oxidoreductin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7FAS8
    Conserved Domains (1) summary
    pfam04137
    Location:54 → 480
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  3. NM_001377682.2 → NP_001364632.1  Endoplasmic reticulum oxidoreductin-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam04137
    Location:2 → 306
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  4. NM_001306232.3 → NP_001293161.1  Endoplasmic reticulum oxidoreductin-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLA8
    Conserved Domains (1) summary
    pfam04137
    Location:1 → 217
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YTU4.2

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