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zoo-1 Tight junction protein ZO-1 [ Caenorhabditis elegans ]

Gene ID: 173316, updated on 4-Jan-2025

Summary

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Official Symbol
zoo-1
Official Full Name
Tight junction protein ZO-1
Primary source
WormBase:WBGene00013683
Locus tag
CELE_Y105E8A.26
See related
AllianceGenome:WB:WBGene00013683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cell adhesion molecule binding activity. Involved in actin filament organization; embryo development; and embryonic morphogenesis. Located in adherens junction and bicellular tight junction. Is expressed in muscle cell. Human ortholog(s) of this gene implicated in disease of metabolism and progressive familial intrahepatic cholestasis 4. Orthologous to several human genes including TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See zoo-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (14529529..14546870)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein;TFIIIC_sub6 domain-containing protein Neighboring gene Chloride intracellular channel exc-4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans. Koterniak B, et al. Genome Res, 2020 Dec. PMID 33127752, Free PMC Article
  2. The C. elegans zonula occludens ortholog cooperates with the cadherin complex to recruit actin during morphogenesis. Lockwood C, et al. Curr Biol, 2008 Sep 9. PMID 18718757, Free PMC Article
  3. Impaired immune response and barrier function in GSPD-1-deficient C. elegans infected with Klebsiella pneumoniae. Yang WH, et al. Curr Res Microb Sci, 2023. PMID 36798906, Free PMC Article
  4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tight junction protein ZO-1
NP_001252376.1
  • Confirmed by transcript evidence
NP_001252377.1
  • Confirmed by transcript evidence
NP_001252378.1
  • Confirmed by transcript evidence
NP_001364648.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14529529..14546870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001265447.4 → NP_001252376.1  Tight junction protein ZO-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001252376.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I103
    Conserved Domains (4) summary
    cd11859
    Location:420 → 487
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    cd00992
    Location:46 → 128
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00791
    Location:1033 → 1133
    ZU5; ZU5 domain
    cl17190
    Location:539 → 690
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. NM_001377679.2 → NP_001364648.1  Tight junction protein ZO-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q56VX4
    Conserved Domains (4) summary
    cd11859
    Location:420 → 487
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    cd00992
    Location:46 → 128
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00791
    Location:994 → 1094
    ZU5; ZU5 domain
    cl17190
    Location:539 → 690
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  3. NM_001265448.4 → NP_001252377.1  Tight junction protein ZO-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001252377.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UBK9
    Conserved Domains (4) summary
    cd11859
    Location:388 → 455
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    cd00992
    Location:14 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00791
    Location:1001 → 1099
    ZU5; ZU5 domain
    cl17190
    Location:507 → 658
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  4. NM_001265449.3 → NP_001252378.1  Tight junction protein ZO-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001252378.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UBL0
    Conserved Domains (4) summary
    cd11859
    Location:296 → 363
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    cd00992
    Location:202 → 277
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00791
    Location:909 → 1007
    ZU5; ZU5 domain
    cl17190
    Location:415 → 566
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
Nucleotide Protein
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