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unc-95 LIM domain-containing protein unc-95 [ Caenorhabditis elegans ]

Gene ID: 173301, updated on 9-Dec-2024

Summary

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Official Symbol
unc-95
Official Full Name
LIM domain-containing protein unc-95
Primary source
WormBase:WBGene00006824
Locus tag
CELE_Y105E8A.6
See related
AllianceGenome:WB:WBGene00006824
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein domain specific binding activity. Located in M band; nucleus; and striated muscle dense body. Is expressed in anal depressor muscle; anal sphincter muscle; body wall musculature; and vulval muscle. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-95 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (14381360..14384737, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ig-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CUB domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene WD_REPEATS_REGION domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans. Broday L, et al. J Cell Biol, 2004 Jun 21. PMID 15210732, Free PMC Article
  2. Molting-specific downregulation of C. elegans body-wall muscle attachment sites: the role of RNF-5 E3 ligase. Zaidel-Bar R, et al. Biochem Biophys Res Commun, 2010 May 14. PMID 20385102
  3. The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle. Qadota H, et al. Mol Biol Cell, 2016 May 15. PMID 27009202, Free PMC Article
  4. RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. Didier C, et al. Mol Cell Biol, 2003 Aug. PMID 12861019, Free PMC Article
  5. High-resolution imaging of muscle attachment structures in Caenorhabditis elegans. Qadota H, et al. Cytoskeleton (Hoboken), 2017 Nov. PMID 28921913, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in M band IEA
Inferred from Electronic Annotation
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in striated muscle dense body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
LIM domain-containing protein unc-95
NP_740934.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14381360..14384737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170938.7 → NP_740934.2  LIM domain-containing protein unc-95 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740934.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NEZ5
    Conserved Domains (1) summary
    cd09339
    Location:270 → 328
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NEZ5.2

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