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Minpp1 multiple inositol polyphosphate histidine phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 17330, updated on 27-Nov-2024

Summary

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Official Symbol
Minpp1provided by MGI
Official Full Name
multiple inositol polyphosphate histidine phosphatase 1provided by MGI
Primary source
MGI:MGI:1336159
See related
Ensembl:ENSMUSG00000024896 AllianceGenome:MGI:1336159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables inositol phosphate phosphatase activity. Is active in endoplasmic reticulum lumen and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 47.9), duodenum adult (RPKM 37.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Minpp1 in Genome Data Viewer
Location:
19 C1; 19 27.25 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (32463169..32492770)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (32485769..32515370)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9, pseudogene 6 Neighboring gene predicted gene, 46659 Neighboring gene STARR-seq mESC enhancer starr_45949 Neighboring gene predicted gene, 36419 Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene STARR-seq mESC enhancer starr_45950 Neighboring gene predicted gene, 36492

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Ucuncu E, et al. Nat Commun, 2020 Nov 30. PMID 33257696, Free PMC Article
  2. Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo. Chi H, et al. Mol Cell Biol, 2000 Sep. PMID 10938126, Free PMC Article
  3. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. Chi H, et al. Genomics, 1999 Mar 15. PMID 10087200
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia.
    Title: MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phytase activity IEA
Inferred from Electronic Annotation
more info
  
enables 4-phytase activity IEA
Inferred from Electronic Annotation
more info
  
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bisphosphoglycerate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables bisphosphoglycerate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol bisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol bisphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol pentakisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol pentakisphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol phosphate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables inositol trisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol trisphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol-hexakisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-hexakisphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
NOT involved_in bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of intracellular monoatomic cation homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of intracellular monoatomic cation homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of intracellular monoatomic cation homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
multiple inositol polyphosphate phosphatase 1
Names
2,3-BPG phosphatase
2,3-bisphosphoglycerate 3-phosphatase
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
ins(1,3,4,5)P(4) 3-phosphatase
NP_034929.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010799.2 → NP_034929.1  multiple inositol polyphosphate phosphatase 1 precursor

    See identical proteins and their annotated locations for NP_034929.1

    Status: VALIDATED

    Source sequence(s)
    AC115752, AK151486, AV297692
    Consensus CDS
    CCDS29751.1
    UniProtKB/Swiss-Prot
    Q3UA76, Q8VDR0, Q9JJD5, Q9Z2L6
    Related
    ENSMUSP00000025827.9, ENSMUST00000025827.10
    Conserved Domains (1) summary
    cd07061
    Location:82 → 429
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    32463169..32492770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2L6.3 GenPept UniProtKB/Swiss-Prot:Q9Z2L6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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