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taf-1 Bromo domain-containing protein;Transcription initiation factor TFIID subunit 1 [ Caenorhabditis elegans ]

Gene ID: 173257, updated on 23-Jan-2025

Summary

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Official Symbol
taf-1
Official Full Name
Bromo domain-containing protein;Transcription initiation factor TFIID subunit 1
Primary source
WormBase:WBGene00006382
Locus tag
CELE_W04A8.7
See related
AllianceGenome:WB:WBGene00006382
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including RNA polymerase II general transcription initiation factor activity; TBP-class protein binding activity; and histone acetyltransferase activity. Predicted to contribute to transcription cis-regulatory region binding activity. Involved in embryo development and transcription initiation at RNA polymerase II promoter. Located in nucleus. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Orthologous to several human genes including TAF1L (TATA-box binding protein associated factor 1 like). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See taf-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
15
Sequence:
Chromosome: I; NC_003279.8 (13861474..13887640)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene FBA_2 domain-containing protein Neighboring gene ncRNA Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transgenerational response of germline histone acetyltransferases and deacetylases to nanoplastics at predicted environmental doses in Caenorhabditis elegans. Hua X, et al. Sci Total Environ, 2024 Nov 20. PMID 39218082
  2. A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. Giles AC, et al. J Biol Chem, 2019 Apr 26. PMID 30858176, Free PMC Article
  3. Distinct requirements for C.elegans TAF(II)s in early embryonic transcription. Walker AK, et al. EMBO J, 2001 Sep 17. PMID 11566890, Free PMC Article
  4. An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. Walker AK, et al. J Biol Chem, 2004 Apr 9. PMID 14726532
  5. Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase. Whetstine JR, et al. Mol Cell, 2005 May 13. PMID 15893731

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and development
    Title: An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
contributes_to transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Bromo domain-containing protein;Transcription initiation factor TFIID subunit 1
NP_001391087.1
  • Confirmed by transcript evidence
NP_493426.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13861474..13887640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061025.6 → NP_493426.2  Transcription initiation factor TFIID subunit 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493426.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGM3
    Conserved Domains (3) summary
    cd05511
    Location:1413 → 1524
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam12157
    Location:489 → 947
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1217 → 1251
    zf-CCHC_6; Zinc knuckle

  2. NM_001404219.1 → NP_001391087.1  Bromo domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4Q965
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EGM3.1

Gene LinkOut

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