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nyn-2 Zc3h12a-like Ribonuclease NYN domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173226, updated on 4-Jan-2025

Summary

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Official Symbol
nyn-2
Official Full Name
Zc3h12a-like Ribonuclease NYN domain-containing protein
Primary source
WormBase:WBGene00013596
Locus tag
CELE_Y87G2A.7
See related
AllianceGenome:WB:WBGene00013596
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in siRNA processing. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nyn-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (13572379..13575805)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Carbohydrate sulfotransferase Neighboring gene Ground-like domain-containing protein Neighboring gene peptidylprolyl isomerase Neighboring gene Glucose-6-phosphate isomerase Neighboring gene Ubiquitin-conjugating enzyme E2 S

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of the mutator complex triggers a low penetrance larval arrest phenotype. Rogers AK, et al. MicroPubl Biol, 2020. PMID 32542232, Free PMC Article
  2. A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi. Tsai HY, et al. Cell, 2015 Jan 29. PMID 25635455, Free PMC Article
  3. A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans. Manage KI, et al. Elife, 2020 Apr 27. PMID 32338603, Free PMC Article
  4. Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci. Uebel CJ, et al. PLoS Genet, 2018 Jul. PMID 30036386, Free PMC Article
  5. Diversification of small RNA pathways underlies germline RNA interference incompetence in wild Caenorhabditis elegans strains. Chou HT, et al. Genetics, 2024 Jan 3. PMID 37865119, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in siRNA processing IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
Zc3h12a-like Ribonuclease NYN domain-containing protein
NP_001370075.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13572379..13575805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383746.2 → NP_001370075.1  Zc3h12a-like Ribonuclease NYN domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NA28
    Conserved Domains (1) summary
    pfam14626
    Location:261 → 384
    RNase_Zc3h12a_2; Zc3h12a-like Ribonuclease NYN domain
Nucleotide Protein
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