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glp-4 Valine--tRNA ligase [ Caenorhabditis elegans ]

Gene ID: 173224, updated on 9-Dec-2024

Summary

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Official Symbol
glp-4
Official Full Name
Valine--tRNA ligase
Primary source
WormBase:WBGene00006936
Locus tag
CELE_Y87G2A.5
See related
AllianceGenome:WB:WBGene00006936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable valine-tRNA ligase activity. Involved in determination of adult lifespan. Predicted to be active in cytosol. Orthologous to human VARS1 (valyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See glp-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (13548074..13559361, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cysteine protease atg-4.1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene small monomeric GTPase Neighboring gene Carbohydrate sulfotransferase Neighboring gene Ground-like domain-containing protein Neighboring gene peptidylprolyl isomerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yersinia enterocolitica infection and tcaA-dependent killing of Caenorhabditis elegans. Spanier B, et al. Appl Environ Microbiol, 2010 Sep. PMID 20639372, Free PMC Article
  2. Repurposing bioactive compounds for treating multidrug-resistant pathogens. Hummell NA, et al. J Med Microbiol, 2020 Jun. PMID 32163353, Free PMC Article
  3. Early experiences mediate distinct adult gene expression and reproductive programs in Caenorhabditis elegans. Ow MC, et al. PLoS Genet, 2018 Feb. PMID 29447162, Free PMC Article
  4. A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans. Zwirchmayr J, et al. Sci Rep, 2020 Jul 23. PMID 32704017, Free PMC Article
  5. Caenorhabditis elegans glp-4 Encodes a Valyl Aminoacyl tRNA Synthetase. Rastogi S, et al. G3 (Bethesda), 2015 Oct 13. PMID 26464357, Free PMC Article

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables valine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables valine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in valyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in valyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Valine--tRNA ligase
NP_493377.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13548074..13559361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060976.7 → NP_493377.1  Valine--tRNA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493377.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U1Q4
    Conserved Domains (5) summary
    cd07962
    Location:718 → 856
    Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
    cd00817
    Location:118 → 718
    ValRS_core; catalytic core domain of valyl-tRNA synthetases
    PTZ00419
    Location:51 → 1050
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional
    pfam10458
    Location:982 → 1047
    Val_tRNA-synt_C; Valyl tRNA synthetase tRNA binding arm
    pfam13603
    Location:301 → 426
    tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U1Q4.1

Gene LinkOut

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