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snr-2 putative small nuclear ribonucleoprotein-associated protein B [ Caenorhabditis elegans ]

Gene ID: 173204, updated on 4-Jan-2025

Summary

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Official Symbol
snr-2
Official Full Name
putative small nuclear ribonucleoprotein-associated protein B
Primary source
WormBase:WBGene00004915
Locus tag
CELE_W08E3.1
See related
AllianceGenome:WB:WBGene00004915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable snRNP binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nucleus. Predicted to be part of spliceosomal complex and spliceosomal snRNP complex. Predicted to be active in cytoplasm. Is expressed in gonad. Human ortholog(s) of this gene implicated in Prader-Willi syndrome; cerebrocostomandibular syndrome; and mixed connective tissue disease. Orthologous to several human genes including SNURF (SNRPN upstream open reading frame) and SNRPN (small nuclear ribonucleoprotein polypeptide N). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See snr-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (13339397..13340224)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene Obg-like ATPase 1 Neighboring gene WW domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Translational suppression via IFG-1/eIF4G inhibits stress-induced RNA alternative splicing in Caenorhabditis elegans. Chomyshen SC, et al. Genetics, 2022 Jul 4. PMID 35536193, Free PMC Article
  2. A novel function for the Sm proteins in germ granule localization during C. elegans embryogenesis. Barbee SA, et al. Curr Biol, 2002 Sep 3. PMID 12225665
  3. A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex. Fasimoye RY, et al. Nucleic Acids Res, 2022 Jul 22. PMID 35736244, Free PMC Article
  4. Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. Joseph-Strauss D, et al. Dev Biol, 2012 May 15. PMID 22426005, Free PMC Article
  5. The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90. Gaiser AM, et al. J Mol Biol, 2009 Aug 21. PMID 19559711

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables snRNP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative small nuclear ribonucleoprotein-associated protein B
NP_493348.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13339397..13340224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060947.7 → NP_493348.1  putative small nuclear ribonucleoprotein-associated protein B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493348.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91918
    Conserved Domains (1) summary
    cd01717
    Location:5 → 83
    Sm_B; Sm protein B
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91918.1

Gene LinkOut

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