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pde-1 Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-1 [ Caenorhabditis elegans ]

Gene ID: 173200, updated on 4-Jan-2025

Summary

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Official Symbol
pde-1
Official Full Name
Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-1
Primary source
WormBase:WBGene00011433
Locus tag
CELE_T04D3.3
See related
AllianceGenome:WB:WBGene00011433
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of intracellular signal transduction; and response to hydrogen peroxide. Is expressed in head and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to several human genes including PDE1A (phosphodiesterase 1A) and PDE1B (phosphodiesterase 1B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pde-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (13310887..13318716, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene Uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Natural Variation in a Dendritic Scaffold Protein Remodels Experience-Dependent Plasticity by Altering Neuropeptide Expression. Beets I, et al. Neuron, 2020 Jan 8. PMID 31757604, Free PMC Article
  2. Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans. Rojo Romanos T, et al. Sci Rep, 2017 Jan 31. PMID 28139692, Free PMC Article
  3. cGMP dynamics that underlies thermosensation in temperature-sensing neuron regulates thermotaxis behavior in C. elegans. Aoki I, et al. PLoS One, 2022. PMID 36472979, Free PMC Article
  4. GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis. Wang D, et al. J Gen Physiol, 2013 Oct. PMID 24081984, Free PMC Article
  5. The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected]. Beckert U, et al. PLoS One, 2013. PMID 24015261, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemosensory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in microvillus organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cGMP-mediated signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein kinase C signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phototransduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to alkaline pH IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to hydrogen peroxide IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to oxygen levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-1
NP_001129790.1
  • Confirmed by transcript evidence
NP_493343.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13310887..13318716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060942.5 → NP_493343.1  putative 3',5'-cyclic phosphodiesterase pde-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493343.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18696
    Conserved Domains (2) summary
    pfam00233
    Location:332 → 558
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:195 → 248
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  2. NM_001136318.5 → NP_001129790.1  Phosphodiesterase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5BM35
    Conserved Domains (2) summary
    pfam00233
    Location:201 → 427
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:64 → 117
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18696.2

Gene LinkOut

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